| Bioactivity | VIR-165 is a modified form of virus inhibitory peptide (VIRIP) that binds the fusion peptide of the gp41 subunit and prevents its insertion into the target membrane. VIRIP inhibits a wide variety of human immunodeficiency virus type 1 (HIV-1) strains[1]. |
| Name | VIR-165 |
| Sequence | Leu-Glu-Ala-Ile-Pro-Cys-Ser-Ile-Pro-Pro-Cys-Phe-Ala-Phe-Asn-Lys-Pro-Phe-Val-Phe (Disulfide bridge: Cys6-Cys11) |
| Shortening | LEAIPCSIPPCFAFNKPFVF (Disulfide bridge: Cys6-Cys11) |
| Formula | C109H158N22O25S2 |
| Molar Mass | 2240.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Münch J, et al. Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. Cell. 2007 Apr 20;129(2):263-75. [2]. Eggink D, et al. HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike. J Virol. 2016 Nov 14;90(23):10587-10599. |