| Bioactivity | VH-N412 is a vectorized neuropeptide (NT) with good blood-brain barrier permeability. VH-N412 binds to the low-density lipoprotein receptor (LDLR) and neuropeptide receptor 1 (NTSR-1), and acts as a pharmacological-induced hypothermia (PIH) inducer. VH-N412 exhibits anticonvulsant and neuroprotective effects, and can be used in the study of neurological diseases such as epilepsy. [1] |
| CAS | 1801681-81-1 |
| Sequence | Pr-{d-Cys}-Met-{Pip}-Arg-Leu-Arg-{Sar}-Cys-{PEG6}-Arg-Arg-Pro-Tyr-Ile-Leu-OH (Disulfide bridge: Cys1-Cys8) |
| Shortening | Pr-{d-Cys}-M-{Pip}-RLR-{Sar}-C-{PEG6}-RRPYIL-OH (Disulfide bridge: Cys1-Cys8) |
| Formula | C94H163N27O24S3 |
| Molar Mass | 2151.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ferhat L, et al. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice[J]. bioRxiv, 2024: 2024.07. 15.603208. |
VH-N412
CAS: 1801681-81-1 F: C94H163N27O24S3 W: 2151.66
VH-N412 is a vectorized neuropeptide (NT) with good blood-brain barrier permeability. VH-N412 binds to the low-density l
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