| Bioactivity | VGN50 is a bioactive molecule that mimics the function of K-Rta and down-regulates MYC-mediated gene transcription. VGN50 has antitumor activity[1]. |
| Invitro | VGN50 (24 μM, 24 h) 在 BCBL-1 细胞中可下调 MYC 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VGN50 相关抗体: |
| In Vivo | VGN50 (10 mg/kg, 腹腔注射, 连续 10 天) 在 PEL 异种移植小鼠瘤模型中可抑制肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Sequence | {d-Arg}-Lys-Lys-Arg-Arg-{Orn}-Arg-Arg-Arg-{βAla}-Leu-Ser-Ser-Ile-Leu-Gln-Gly-Leu-Tyr-Gln-Leu-Asp-Thr |
| Shortening | {d-Arg}-KKRR-{Orn}-RRR-{βAla}-LSSILQGLYQLDT |
| Formula | C121H218N46O32 |
| Molar Mass | 2829.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shimoda M, et al. KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth. Commun Biol. 2021 Dec 2;4(1):1330. |