| Bioactivity | VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer[1]. |
| Invitro | VEGFR-2/DHFR-IN-2 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 64, 64, 32, 32, 16, 32, 64 and 256 μg/mL for Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, Salmonella enterica, MSSA, MRSA, Candida albicans and Aspergillus niger, respectively[1]. VEGFR-2/DHFR-IN-2 (0.5-100 μM; 48 h) exhibits anticancer activities[1].VEGFR-2/DHFR-IN-2 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC50s of 9.085 and 0.623 μM, respectively[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | VEGFR-2/DHFR-IN-2 |
| Formula | C21H21NO4 |
| Molar Mass | 351.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pham EC, et al. Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors. ACS. 2022. |