| Bioactivity | VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential[1]. |
| Target | AURKA, VEGFR-2 |
| Name | VEGFR-2/AURKA-IN-1 |
| Formula | C20H15ClF6N2O4S |
| Molar Mass | 528.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. D Shankara S et al. Vetting of New 2, 5-Bis (2, 2, 2-trifluoroethoxy) Phenyl-Linked 1, 3-Thiazolidine-4-one Derivatives as AURKA and VEGFR-2 Inhibitor Antiglioma Agents Assisted with In Vitro and In Silico Studies[J]. ACS Omega, 2023. |
VEGFR-2/AURKA-IN-1
CAS: F: C20H15ClF6N2O4S W: 528.85
VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEG
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