| Bioactivity | VEGFR-2-IN-62 (Compound 3f) is an effective VEGFR-2 inhibitor with an IC50 value of 0.0557 μM. VEGFR-2-IN-62 can inhibit cell proliferation and induce apoptosis, and can be used in cancer research[1]. |
| Invitro | VEGFR-2-IN-62 (Compound 3f) (0.08 μM; 24 h) 在 MCF-7 细胞中可以诱导细胞凋亡，能显著提高 Bax 水平并下调 Bcl2 水平，同时极大地增加 Bax/Bcl2 比例[1]。VEGFR-2-IN-62 对 HepG2、MCF-7 和 VERO 人肿瘤细胞系具有抗增殖活性，其 IC50 值分别为 0.17、0.08 和 1.98 μM[1]。VEGFR-2-IN-62 (2.3 μM; 24 h) 可以将 MCF-7 细胞周期阻滞在 G2-M 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VEGFR-2-IN-62 相关抗体: Apoptosis Analysis[1] Cell Line: |
| Formula | C26H18ClN5O2 |
| Molar Mass | 467.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bayoumi H H, et al. Phthalazine Derivatives as VEGFR‐2 Inhibitors: Docking, ADMET, Synthesis, Design, Anticancer Evaluations, and Apoptosis Inducers[J]. Drug Development Research, 2025, 86(1): e70037. |