| Bioactivity | VEGFR-2-IN-53 (Compound 15w) is a VEGFR-2 inhibitor with an IC50 of 4.34 μM. VEGFR-2-IN-53 induces apoptosis by inhibiting VEGFR-2 activity and preventing cell migration, thereby exhibiting anti-angiogenic effects. The IC50 value of VEGFR-2-IN-53 for inhibiting MCF-7 cell growth is 3.87 μM. VEGFR-2-IN-53 can be used in cancer research[1]. |
| Formula | C29H23N5O2S |
| Molar Mass | 505.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Valapil DG, et al. Design, development of pyrazole-linked spirocyclopropyl oxindole-carboxamides as potential cytotoxic agents and Type III allosteric VEGFR-2 inhibitors. ChemMedChem. 2024 Aug 1:e202400422. |