| Bioactivity | VEGFR-2-IN-50 (Compound 10f) is a VEGFR-2 inhibitor and apoptosis inducer, with an IC50 value of 0.33 μM. VEGFR-2-IN-50 (Compound 10f) has growth inhibitory activity on MCF-7 and MDA-MB-231 breast cancer cell lines, with IC50 values of 19.86 μM and 10.88 μM, respectively, which is expected to be used in the study of breast cancer diseases[1]. |
| Target | IC50: 0.33 μM (VEGFR-2). |
| Invitro | VEGFR-2-IN-50 (Compound 10f) 对 MCF-7 和 MDA-MB-231 乳腺癌细胞系具有生长抑制活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VEGFR-2-IN-50 相关抗体: |
| Formula | C23H16BrN5O |
| Molar Mass | 458.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mahmoud S. Elkotamy, et al. Novel imidazo[2,1-b]thiazoles and imidazo[1,2-a]pyridines tethered with indolinone motif as VEGFR-2 inhibitors and apoptotic inducers: Design, synthesis and biological evaluations. Bioorganic Chemistry. 2024 Oct; 151: 107644. |