| Bioactivity | VEGFR-2-IN-46 (compound 4d) is a potent VEGFR-2 inhibitor with an EC50 value of 67.0 nM. VEGFR-2-IN-46 shows cytotoxicity and induces cell cycle arrest at the G2/M phase. VEGFR-2-IN-46 induces necrosis and apoptosis[1]. |
| Invitro | VEGFR-2-IN-46 (compound 4d) 对 HT-29、HeLa、HepG2、MCF10A 细胞表现出细胞毒性，IC50 值分别为 501、34.3、25.0、128.7 µM[1]。VEGFR-2-IN-46 (25 µM; 72 h) 诱导细胞周期停滞在 G2/M 期，并诱导 HepG2 细胞坏死、凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VEGFR-2-IN-46 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Formula | C23H18N2O4S |
| Molar Mass | 418.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Heriz MH, et al. Synthesis, docking study, and antitumor evaluation of benzamides and oxadiazole derivatives of 3-phenoxybenzoic acid as VEGFR-2 inhibitors. Drug Dev Res. 2024 May;85(3):e22186. |