| Bioactivity | VEGFR-2-IN-30 is a VEGFR-2 inhibitor (IC50: 66 nM). VEGFR-2-IN-30 also inhibits PDGFR, EGFR and FGFR1 with IC50s of 180, 98, 82 nM respectively. VEGFR-2-IN-30 arrests cancer cell at S-phase and induces early and late apoptosis[1]. |
| Invitro | VEGFR-2-IN-30 (化合物 8f) (10 μM) 抑制 35% 的 UO-31 细胞生长[1]。VEGFR-2-IN-30 (10 μg/mL, 72 h) 抑制 HUVEC 细胞迁移[1].VEGFR-2-IN-30 (5.29 μM, 24 h) 在阻滞 UO-31 细胞 在S 期[1]。VEGFR-2-IN-30 (5.29 μM, 24 h) 诱导 UO-31 细胞凋亡[1]。VEGFR-2-IN-30 (5.29 μM, 24 h) 在 UO-31 细胞中增加 Bax 水平并下调 Bcl-2 水平[1]。 Cell Migration Assay [1] Cell Line: |
| Name | VEGFR-2-IN-30 |
| Formula | C28H23ClN6O4S2 |
| Molar Mass | 607.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zahran SS, et al. Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4(3H)-ones and sulfachloropyridazine. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114912. |