| Bioactivity | VD4162 (Compound 8b) is a macrocyclic inhibitor of serine proteases. VD4162 can significantly improve potency for all four target enzymes TMPRSS2 (IC50 = 3.7 nM), HGFA(IC50 = 3.3 nM), matriptase (IC50 = 2.9 nM), and hepsin (IC50 = 0.54 nM). VD4162 can be used for the research of cancer[1]. |
| CAS | 2574390-19-3 |
| Formula | C41H47N9O6S |
| Molar Mass | 793.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Damalanka VC, et al. Mechanism-Based Macrocyclic Inhibitors of Serine Proteases. J Med Chem. 2024 Mar 28;67(6):4833-4854. |