VCP/p97 inhibitor-1_product_DataBase

Bioactivity	VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].
Target	54.7 nM (VCP/p97)
Invitro	VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1]. 0 --> VCP/p97 inhibitor-1 相关抗体: Cell Viability Assay[1] Cell Line:
Name	VCP/p97 inhibitor-1
CAS	2630950-38-6
Formula	C24H26BN5O4S
Molar Mass	491.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang Y, et al. Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors. Bioorg Med Chem. 2021;38:116114. [2]. van den Boom J, et al. VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling. Mol Cell. 2018;69(2):182-194.

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