| Bioactivity | VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. | |||||||||
| Target | Kd: 17 μM (VDAC1)Apoptosis | |||||||||
| Invitro | VBIT-4 靶向线粒体蛋白 VDAC1，抑制细胞凋亡并防止线粒体功能障碍。VBIT-4 (0.1-10 μM) 抑制 HEK-293 细胞中的 VDAC1 寡聚化、Cyto c 从线粒体释放和细胞凋亡，IC50 分别为 1.9±0.08 μM、1.8±0.24 μM 和 2.9±分别为 0.12 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VBIT-4 相关抗体: Apoptosis Analysis[1] Cell Line: | |||||||||
| CAS | 2086257-77-2 | |||||||||
| Formula | C21H23ClF3N3O3 | |||||||||
| Molar Mass | 457.87 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003. |
VBIT-4
CAS: 2086257-77-2 F: C21H23ClF3N3O3 W: 457.87
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17
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