| Bioactivity | VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3 μM. VBIT-3, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. |
| Target | Kd: 31.3 μM (VDAC1)Apoptosis |
| Invitro | VBIT-3 targets the mitochondrial protein VDAC1, inhibit apoptosis and protect against mitochondria dysfunction[1]. VBIT-3 (0.1-10 μM) inhibits VDAC1 oligomerization, Cyto c release from mitochondria and apoptosis in HEK-293 cells with IC50s of 8.8±0.56 μM, 6.6±1.03 μM, and 7.5±0.27 μM, respectively[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VBIT-3 相关抗体: Apoptosis Analysis[1] Cell Line: |
| CAS | 2088463-66-3 |
| Formula | C21H19ClF3N3O3 |
| Molar Mass | 453.84 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003. |
VBIT-3
CAS: 2088463-66-3 F: C21H19ClF3N3O3 W: 453.84
VBIT-3 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 31.3
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