| Bioactivity | VBIT-12 is a potent VDAC1 inhibitor. VBIT-12 directly interacts with VDAC1 and prevents VDAC1 oligomerization, and thus inhibits apoptotic action of VDAC1[1]. |
| Target | VDAC1 |
| Invitro | VBIT-12 inhibits VDAC1 oligomerization, hexokinase (HK) detachment and apoptotic cell death[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VBIT-12 相关抗体: |
| CAS | 2089227-65-4 |
| Formula | C25H27N3O3 |
| Molar Mass | 417.50 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Shoshan-Barmatz V, et al. VDAC1, mitochondrial dysfunction, and Alzheimer's disease. Pharmacol Res. 2018 May;131:87-101. |