| Bioactivity | V-0219 (Compound 9) is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R). V-0219 can be used for obesity-associated diabetes research[1]. | |||||||||
| Target | GLP-1R | |||||||||
| Name | V-0219 | |||||||||
| CAS | 878453-71-5 | |||||||||
| Formula | C20H25F3N4O2 | |||||||||
| Molar Mass | 410.43 | |||||||||
| Appearance | Oil | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461. |