| Bioactivity | Utrophin modulator 1 is a potent utrophin modulator (upregulates utrophin protein levels), with an EC50 of 0.11 μM. Utrophin modulator 1 can be used in study of duchenne muscular dystrophy (DMD)[1]. |
| Invitro | Utrophin modulator 1 (compound 76) (0.1, 1.0, 10 μM; 24 h) upregulates utrophin protein levels in H2K-mdx cells[1]. Western Blot Analysis[1] Cell Line: |
| Name | Utrophin modulator 1 |
| Formula | C22H18N6O |
| Molar Mass | 382.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chatzopoulou M, et al. Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy. Bioorg Med Chem. 2022 Sep 1;69:116812. |