| Bioactivity | Upadacitinib-15N,d2 (ABT-494-15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib-15N,d2 (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib-15N,d2 (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib-15N,d2 (ABT-494) can be used for several autoimmune disorders research[1][2]. | ||||||||||||
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 0 --> Upadacitinib-15N,d2 相关抗体: | ||||||||||||
| Name | Upadacitinib-15N,d2 | ||||||||||||
| Formula | C17H17D2F3N515NO | ||||||||||||
| Molar Mass | 383.37 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Upadacitinib-15N,d2
CAS: F: C17H17D2F3N515NO W: 383.37
Upadacitinib-15N,d2 (ABT-494-15N,d2) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib-15N,d2 (ABT-494) is
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