| Bioactivity | Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2]. |
| Invitro | Ulinastatin（500-5000 U；24 小时）可显着减弱 LPS 刺激的 BEAS-2B 细胞中的 TLR4 表达和 NF-κB 激活[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | Ulinastatin（10000 U/kg；静脉注射；两次）显着保护动物免受 LPS 诱导的急性肺损伤 (ALI)，降低肺湿/干重比、ALI 评分、总细胞、中性粒细胞、巨噬细胞、髓过氧化物酶活性和丙二醛含量 、与肺组织学损伤相关的因素[1]。 Animal Model: |
| Name | Ulinastatin |
| CAS | 80449-31-6 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726. [2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605. |