Ubiquitination-IN-3_product_DataBase

Bioactivity	Ubiquitination-IN-3 is a potent E1-E2 protein−protein interactions (PPI) inhibitor. Ubiquitination-IN-3 has a Kd value of 0.72 μM for ubiquitin E1 (Uba1). Ubiquitination-IN-3 inhibits blocks ubiquitin transfer from E1 to E2. Ubiquitination-IN-3 can be used in research of cancer[1].
Invitro	Ubiquitination-IN-3 (M1-S2; 0-50 μM; 16 h; HEK293T 细胞) 通过阻断 CHIP 催化的单泛素化来抑制泛素向底物蛋白 CDK4 的转移[1] 。Ubiquitination-IN-3 (0-50 μM; HEK293T 细胞) 通过与 E1 酶 Uba1 结合并阻断从 E1 到 E2 的泛素转移来抑制蛋白质泛素化级联[1]。Ubiquitination-IN-3 (0-50 μM; HEK293T 细胞) 抑制泛素转移到不同类型的 E2 酶，在 50 μM 浓度下抑制 E2-UB 结合物的形成[1]。 Western Blot Analysis[1] Cell Line:
Name	Ubiquitination-IN-3
Formula	C90H168N26O28S8
Molar Mass	2318.97
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhou L, et, al. Inhibition of the Ubiquitin Transfer Cascade by a Peptidomimetic Foldamer Mimicking the E2 N-Terminal Helix. J Med Chem. 2023 Jan 12;66(1):491-502.

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