| Bioactivity | Ub4ix is a proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM[1]. |
| CAS | 2396736-46-0 |
| Sequence | cyclo(Ac-{d-Trp}-Leu-Tyr-Leu-Asp-Asp-Ser-Gly-Asp-Trp-Trp-Ile-Cys)-Gly-NH2, cyclized via thioether |
| Shortening | cyclo(Ac-{d-Trp}-LYLDDSGDWWIC)-G-NH2, cyclized via thioether |
| Formula | C84H106N18O23S |
| Molar Mass | 1767.91 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nawatha M, et al. De novo macrocyclic peptides that specifically modulate Lys48-linked ubiquitin chains. Nat Chem. 2019 Jul;11(7):644-652. |
Ub4ix
CAS: 2396736-46-0 F: C84H106N18O23S W: 1767.91
Ub4ix is a proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzyme
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