| Bioactivity | UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50s of 0.10 μM and 2.00 μM for inhibiting PGE2 production in human (SK-N-AS) and murine (BV2) cells, respectively[1]. |
| In Vivo | UT-11 (10 mg/kg; i.p.; twice) 抑制 LPS (HY-D1056) 诱导的炎症小鼠模型的神经炎症[1]。 Animal Model: |
| Name | UT-11 |
| Formula | C17H19Cl2N3O2S |
| Molar Mass | 400.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sluter MN, et al. Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):587-599. |