| Bioactivity | USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase[1]. |
| Target | IC50: 7.2 µM (USP10) |
| Invitro | USP10-IN-3 (compound D1) (0-100 µM) 抑制细胞增殖，对 Huh-7 细胞的 IC50 值为 2.3 µM[1]。USP10-IN-3 (compound D1) (0-10 µM; 24 h) 以剂量依赖性方式诱导细胞凋亡和细胞周期停滞在 S 期[1]。USP10-IN-3 (compound D1) (0-30 µM; 24 h) 以剂量依赖性方式降低 YAP1、p53、p21 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> USP10-IN-3 相关抗体: Apoptosis Analysis[1] Cell Line: |
| Formula | C29H25ClN4O3 |
| Molar Mass | 512.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lu Y, et al. Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression. Eur J Med Chem. 2024 Jun 5;272:116468. |