| Bioactivity | URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH[1][2]. |
| In Vivo | URB694 (0.3 mg/kg; i.p.) 增加了 HAB 大鼠张开双臂的时间，且不影响整体运动活动[1]。URB694 (0.3 mg/kg; i.p.) 减少 HAB 大鼠中盐酸异丙肾上腺素 (ISOP; HY-B0468) 诱导的心律失常发生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 904672-77-1 |
| Formula | C19H21NO3 |
| Molar Mass | 311.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218. [2]. Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55(12):1993-7. |