URAT1 inhibitor 11_product_DataBase

Bioactivity	URAT1 inhibitor 11 (Compound 7) is a URAT1 inhibitor with an IC50 value of 0.18 μM. URAT1 inhibitor 11 exhibits potent hypouricemic effects in hyperuricemic zebrafish induced by Potassium oxonate (HY-17511) and Xanthine sodium salt (HY-W017389)[1].
Invitro	URAT1 inhibitor 11 (60 min) 在小鼠肝微粒体中比 Benzbromarone (HY-B1135) 稳定 (残留率分别为83.2 %和4.5 %)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> URAT1 inhibitor 11 相关抗体:
In Vivo	URAT1 inhibitor 11 (0.5 μM) 对 Potassium oxonate (HY-17511) 和 Xanthine sodium salt (HY-W017389) 诱导的高尿酸血症斑马鱼具有降尿酸作用，可减少血液中尿酸水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2416416-13-0
Formula	C20H16F4N2O2
Molar Mass	392.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hou X, et al. Identification of N-phenyl-N-(quinolin-4-yl) amino carboxylic acids as URAT1 inhibitors with hypouricemic effects. Bioorg Med Chem Lett. 2024 Dec 4;117:130053.

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