| Bioactivity | UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates[1]. |
| CAS | 591242-60-3 |
| Formula | C20H15ClN2O5S |
| Molar Mass | 430.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039. |