| Bioactivity | UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/kg i.v. in mice[1]. |
| Target | IC50: 1.1±0.8 nM (MERTK) , 5.3±2.7 nM (AXL) |
| Invitro | UNC8969 (0-1000 nM, 2 h) 剂量依赖性地抑制 pMERTK 和 pAXL[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UNC8969 相关抗体: |
| Formula | C29H41N7O3 |
| Molar Mass | 535.68 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors. J Med Chem. 2024 Apr 11;67(7):5866-5882. |