| Bioactivity | UNC8732 is a targeted protein degradation (TPD) agent. It generates aldehyde metabolites through amine oxidase catalysis, which bind to C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. The recruited FBXO22 further induces degradation of histone methyltransferases and the oncogene NSD2[1]. |
| CAS | 2929304-05-0 |
| Formula | C35H39N5O5 |
| Molar Mass | 609.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nie DY, et al. Recruitment of FBXO22 for targeted degradation of NSD2. Nat Chem Biol. 2024 Jul 4. |