| Bioactivity | UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more than 100-fold selective for CBX7 over the other nine members of this methyl-lysine (Kme) reader panel. |
| CAS | 1872382-48-3 |
| Sequence | {Phe<P-tert-butylbenzoyl>}-Ala-Leu-{Lys<Et,Et>}-{Ser<Me>} |
| Shortening | {Phe<P-tert-butylbenzoyl>}-AL-{Lys<Et,Et>}-{Ser<Me>} |
| Formula | C45H67F3N6O10 |
| Molar Mass | 909.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Stuckey JI, et al. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7. |
UNC3866 TFA
CAS: 1872382-48-3 F: C45H67F3N6O10 W: 909.04
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen (IC50=66±1.2 nM) and is more
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