| Bioactivity | UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1]. |
| Invitro | 与 WT 53BP1TT 不同，53BP1TT-PN 不会与 UNC3474 相互作用[1]。 0 --> UNC3474 相关抗体: |
| Name | UNC3474 |
| CAS | 1648707-79-2 |
| Formula | C17H28N2O |
| Molar Mass | 276.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cui G, et al. An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. bioRxiv [Preprint]. 2023 Jul 18:2023.04.20.534960. |