| Bioactivity | UNC10245380 is a CIB1 inhibitor with an IC50 value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research[1][2]. |
| Target | IC50 = 8 μM (Calcium and Integrin Binding Protein 1 (CIB1)) |
| Invitro | UNC10245380 (30 μM, 24 小时) 在 CIB1 耗竭敏感的三阴性乳腺癌 (TNBC) 细胞中显示出特异性杀伤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UNC10245380 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C30H32ClN5O3S |
| Molar Mass | 578.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. An Y, et al. In silico fragment-based discovery of CIB1-directed anti-tumor agents by FRASE-bot. Nat Commun. 2024 Jul 2;15(1):5564. [2]. Chung AH, et al. CIB1 depletion with docetaxel or TRAIL enhances triple-negative breast cancer cell death. Cancer Cell Int. 2019 Feb 4;19:26. |