| Bioactivity | UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2]. |
| Target | IC50: 0.117 μM (E. coli GUS)EC50: 74±7 nM (E. coli) |
| Invitro | UNC10201652 exhibits potently inhibitory activity against wild type E. coli with an EC50 of 74±7 nM[2]. |
| Name | UNC10201652 |
| CAS | 372495-52-8 |
| Formula | C20H25N7OS |
| Molar Mass | 411.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jariwala PB, et al. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS Chem Biol. 2020 Jan 17;15(1):217-225. [2]. Pellock SJ, et al. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci. 2018 Jul 25;4(7):868-879. |
UNC10201652
CAS: 372495-52-8 F: C20H25N7OS W: 411.52
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117
Data collection：peptidedb@qq.com
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