| Bioactivity | UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces [3H]NCS-382 with an IC50 of 38 nM in rat cerebrocortical membranes. UMB68 sodium has no significant affinity at GABAB receptors, cannot be metabolized to GABA-active compounds[1]. |
| Target | GHB receptor |
| Invitro | UMB68 inhibits [3H]NCS382 (16 nM) binding to the rat cerebrocortical membranes, with an IC50 of 38 nM compared with 25 μM for GHB[1].UMB68 shows no affinity (IC50 >100 μM) at GABA(A) or GABA(B) receptors[1]. |
| In Vivo | UMB68 (320-1778 mg/kg; i.p.) decreases markedly lever pressing in rats[1]. Animal Model: |
| Name | UMB68 sodium |
| CAS | 581099-89-0 |
| Formula | C6H11NaO3 |
| Molar Mass | 154.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu H, et, al. A tertiary alcohol analog of gamma-hydroxybutyric acid as a specific gamma-hydroxybutyric acid receptor ligand. J Pharmacol Exp Ther. 2003 May;305(2):675-9. |
UMB68 sodium
CAS: 581099-89-0 F: C6H11NaO3 W: 154.14
UMB68 sodium is a selective GHB receptor ligand. UMB68 sodium displaces NCS-382 with an IC50 of 38 nM in rat cerebrocort
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