| Bioactivity | ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines[1]. |
| Invitro | ULK1-IN-3 (0-20 μM, 72 小时) 对 786-O, MCF-7, SW620 和 T-24 结肠癌细胞系均具有有效的生长抑制作用，且对 SW620 细胞最有效，LC50值为 3.2 μM，效力略高于 5-Fluorouracil (HY-90006)[1]。ULK1-IN-3 (1.25-10 μM, 24 小时) 诱导 SW620 细胞 G2/M 和 S 期细胞阻滞[1].ULK1-IN-3 (1.25-5 μM, 48 小时) 在 SW620 细胞中可能通过提高 ROS 的产生触发经典的凋亡途径。此外，ULK1-IN-3 上调 SW620细胞中 cleaved PARP (cPARP) 和 NFκβ，AMPK 的表达，但下调 AKT 的表达[1].ULK1-IN-3 对癌细胞活力抑制作用的 LC50 值[1]药代动力学分析[1]Compounds |
| Formula | C25H21ClO5 |
| Molar Mass | 436.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shamsudin NF, et al. A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer. Future Med Chem. 2024 Jul 1:1-19. |