| Bioactivity | UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresses human T-lymphocyte activation in vitro. UK-78,282 binds to residues at the inner surface of the channel overlapping the site of action of verapamil[1]. | |||||||||
| Target | IC50: 200 nM (Kv1.3) | |||||||||
| Name | UK-78282 hydrochloride | |||||||||
| CAS | 136647-02-4 | |||||||||
| Formula | C29H36ClNO2 | |||||||||
| Molar Mass | 466.05 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. D C Hanson, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16 |
UK-78282 hydrochloride
CAS: 136647-02-4 F: C29H36ClNO2 W: 466.05
UK-78282, a novel piperidine, potent and selective Kv1.3 blocker with an IC50 of 200 nM. UK-78,282 effectively suppresse
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