| Bioactivity | UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent | |||||||||
| Name | UK-383367 | |||||||||
| CAS | 348622-88-8 | |||||||||
| Formula | C15H24N4O4 | |||||||||
| Molar Mass | 324.38 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418. [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562. |
UK-383367
CAS: 348622-88-8 F: C15H24N4O4 W: 324.38
UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Select
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