| Bioactivity | UHMCP1 dihydrochloride is a potent UHM domain splicing inhibitor with a Kd value of 79 µM. UHMCP1 dihydrochloride prevents the SF3b155/U2AF65 interaction. UHMCP1 dihydrochloride impacts cell viability and RNA splicing[1]. |
| Target | Kd: 79 µM (UHM domain) |
| Invitro | UHMCP1 dihydrochloride (0-100 µM; 24 h) impacts cell viability and splicing with an EC50 value of 140 µM in HEK293 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | UHMCP1 dihydrochloride |
| Formula | C19H29Cl2N3 |
| Molar Mass | 370.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kobayashi A, et al. Identification of a small molecule splicing inhibitor targeting UHM domains. FEBS J. 2022 Feb;289(3):682-698. |
UHMCP1 dihydrochloride
CAS: F: C19H29Cl2N3 W: 370.36
UHMCP1 dihydrochloride is a potent UHM domain splicing inhibitor with a Kd value of 79 µM. UHMCP1 dihydrochloride preve
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