| Bioactivity | UH15-38 is a potent RIPK3 inhibitor with an IC50 value of 20 nM. UH15-38 blocks IAV (influenza A virus)-activated necroptosis. UH15-38 dampens IAV-induced lung injury[1]. |
| Invitro | UH15-38 (0-1000 nM; 12 h) 以剂量依赖性方式降低 TCZ 诱导的 pMLKL 表达[1]。UH15-38 (0-1000 nM) 保护 I 型肺泡上皮细胞免受典型 TNF 诱导的坏死性凋亡，并防止 IAV 诱导的坏死性凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UH15-38 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | UH15-38 (30 mg/kg; i.p.; daily for 4 days) 可抑制 IAV (甲型流感病毒) 引起的肺损伤[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2540881-21-6 |
| Formula | C26H27N5O2 |
| Molar Mass | 441.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gautam A, et al. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr;628(8009):835-843. |