| Bioactivity | UCSF924 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole[1]. | ||||||||||||
| Target | Ki: 3 nM (dopamine D4 receptor) | ||||||||||||
| Name | UCSF924 | ||||||||||||
| CAS | 1434515-70-4 | ||||||||||||
| Formula | C20H22N2O2 | ||||||||||||
| Molar Mass | 322.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wang S, et al. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science. 2017 Oct 20;358(6361):381-386. |