| Bioactivity | UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decreases Ras activation and induces cell death by autophagy and apoptosis[1]. |
| Target | IC50: 2 μM (2 μM). |
| Name | UCM-1336 |
| CAS | 1621535-90-7 |
| Formula | C26H37N3O2 |
| Molar Mass | 423.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nagore Marín-RamosA, Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia. J Med Chem. 2019 Jul 11;62(13):6035-6046. |
UCM-1336
CAS: 1621535-90-7 F: C26H37N3O2 W: 423.59
UCM-1336 is a potent ICMT inhibitor, with an IC50 of 2 μM. UCM-1336 induces mislocalization of endogenous Ras, decrease
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.