| Bioactivity | UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells[1]. |
| Target | IC50: 3.8 µM (UCK2) |
| Invitro | UCK2 Inhibitor-2 (compound 20874830) 在浓度为 50 µM 时对 K562 细胞中的尿苷补救有 52% 的抑制作用。DHODH 的抑制增加了尿苷的回收，而 UCK2 抑制剂 UCK2 Inhibitor-2 (compound 20874830) 可以抑制这种增加[1]。 |
| Name | UCK2 Inhibitor-2 |
| CAS | 866842-71-9 |
| Formula | C28H23N3O4S |
| Molar Mass | 497.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ayse Okesli-Armlovich, et al. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2559-2564. |
UCK2 Inhibitor-2
CAS: 866842-71-9 F: C28H23N3O4S W: 497.56
UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC50 value of 3.8 µM. UCK2 Inh
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