| Bioactivity | UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal Hydrolase L1 (UCHL1), with an IC50 of 5.1 μM. UCHL1-IN-1 can be used for cancer research[1]. |
| Invitro | UCHL1-IN-1 (0-50 μM，4 小时) 抑制 BT549 细胞中的 UCHL1[1]。UCHL1-IN-1 (0-50 μM，24 小时) 抑制 BT549 细胞的细胞迁移和细胞活力[1]。UCHL1-IN-1 在人肝微粒体检测中代谢相对稳定，t1/2 > 120 分钟，内在肝清除率较低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UCHL1-IN-1 相关抗体: |
| Formula | C11H13Cl2N3O2 |
| Molar Mass | 290.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Imhoff RD, et al. Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1. J Med Chem. 2024 Mar 15. |