| Bioactivity | UBP 1112 is a selective group III mGluR antagonist, with a Kd of 5.1 μM.UBP 1112 shows 96-fold affinity for group III over group II mGlu receptor (Kd, 488 μM), and shows no significant activity at group I mGlu receptor or iGlu receptor[1]. |
| Target | Kd: 5.1 μM (group III mGluR), 488 μM (group II mGluR) |
| Invitro | UBP 1112 可拮抗 (S)-AP4 诱发的背根诱发腹根电位快速成分的抑制，表观 KD 为 5.1 μM。 UBP 1112 还可拮抗 (S)-AP4 引起的突触传递抑制，pA2 为 5.3。此外，UBP 1112 (1 mM) 对 (S)-3,5-DHPG、NMDA、AMPA 或海人酸引起的运动神经元反应几乎没有活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> UBP 1112 相关抗体: |
| CAS | 339526-74-8 |
| Formula | C10H14NO5P |
| Molar Mass | 259.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miller JC, et al. Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals. Br J Pharmacol. 2003 Aug;139(8):1523-31. |