| Bioactivity | UB-165 fumarate is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for nicotine binding in rat brain[1]. |
| Target | Ki: 0.27 nM (nicotine in rat brain). |
| Invitro | UB-165 stimulates [3H]-dopamine release from striatal synaptosomes with EC50 values of 2.4, 134, and 88 nM, and relative efficacies of 1:0.4:0.2, respectively[1]. |
| Name | UB-165 fumarate |
| Formula | C17H19ClN2O4 |
| Molar Mass | 350.80 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Christopher G. V. Sharples, et al. UB-165: A Novel Nicotinic Agonist with Subtype Selectivity Implicates the α4β2* Subtype in the Modulation of Dopamine Release from Rat Striatal Synaptosomes. Journal of Neuroscience 15 April 2000, 20 (8) 2783-2791. |