| Bioactivity | U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-activity relationship, a potent nanomolar inhibitor with inhibitory effects on both HIV-1 and HIV-2 proteases was designed, and its binding mode was studied by X-ray crystallography and molecular modeling. |
| CAS | 124020-62-8 |
| Sequence | Val-Ser-Gln-Asn-Leuψ[CH(OH)CH2]-Val-Ile-Val |
| Shortening | VSQN-Leuψ[CH(OH)CH2]-VIV |
| Formula | C40H73N9O12 |
| Molar Mass | 872.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs |
U-85548E
CAS: 124020-62-8 F: C40H73N9O12 W: 872.06
U-85548E is an HIV protease inhibitor with nanomolar affinity for HIV-1 aspartic protease. By studying its structure-act
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