| Bioactivity | U-69593 is a potent and selective κ1-opioid receptor agonist[1]. U-69593 attenuates cocaine-induced behavioral sensitization in the rat[2]. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice[3]. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum[4]. | |||||||||
| In Vivo | U-69593 (0.16 mg/kg; s.c.) attenuates cocaine-induced behavioral sensitization in the rat[2].U-69593 (1, 10, 25 nmol/µL; Microinjection) reduces anxiety and enhances spontaneous alternation memory in mice[3].U-69593 (0.32 mg/kg; s.c.) decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum[4]. Animal Model: | |||||||||
| Name | U-69593 | |||||||||
| CAS | 96744-75-1 | |||||||||
| Formula | C22H32N2O2 | |||||||||
| Molar Mass | 356.50 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Lahti RA, et al. [3H]U-69593 a highly selective ligand for the opioid kappa receptor. Eur J Pharmacol. 1985 Feb 26;109(2):281-4. [2]. [2]Heidbreder CA, et al. The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat. Brain Res. 1993 Jul 9;616(1-2):335-8. [3]. [3]Wall PM, et al. U-69,593 microinjection in the infralimbic cortex reduces anxiety and enhances spontaneous alternation memory in mice. Brain Res. 2000 Feb 21;856(1-2):259-80. [4]. [4]Gray AM, et al. The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum. J Neurochem. 1999 Sep;73(3):1066-74. |
U-69593
CAS: 96744-75-1 F: C22H32N2O2 W: 356.50
U-69593 is a potent and selective κ1-opioid receptor agonist. U-69593 attenuates cocaine-induced behavioral sensitizati
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