| Bioactivity | U-51605 is a platelet aggregation inhibitor and inhibits thromboxane synthesis. U-51605 is also a prostaglandin I2 synthase inhibitor and can inhibit the retinal vasodilation response induced by NO donors (such as NOR3)[1][2]. |
| Target | Prostaglandin I2 synthase inhibitor 9α |
| Invitro | U-51605 (3 μM) 抑制乙酰胆碱诱导的内皮依赖性收缩[1]。U-51605 (0.5, 1, 3, 10 μM) 增加乙酰胆碱诱导的 PGE2 和 PGF2α 释放[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> U-51605 相关抗体: |
| CAS | 64192-56-9 |
| Formula | C20H32N2O2 |
| Molar Mass | 332.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Needleman P, Bryan B, Wyche A, et al. Thromboxane synthetase inhibitors as pharmacological tools: differential biochemical and biological effects on platelet suspensions[J]. Prostaglandins, 1977, 14(5): 897-907. [2]. Mori A, Namekawa R, Hasebe M, et al. Involvement of prostaglandin I2 in nitric oxide-induced vasodilation of retinal arterioles in rats[J]. European Journal of Pharmacology, 2015, 764: 249-255. |