| Bioactivity | U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC50 of 2.7 nM. U-101958 maleate behaves as an agonist in HEK-293 cells expressing the human recombinant D4.4 receptor. U-101958 maleate is an antipsychotic[1][2]. |
| Invitro | U-101958 以浓度依赖性方式抑制 HEK293/D4 细胞中 Forskolin (HY-15371) 刺激的环磷酸腺苷积累[1]。[3H]PNU-101958 是一种 D4 受体探针。非人类灵长类动物大脑中的 [3H]PNU-101958 结合位点似乎反映了 D4 多巴胺受体的分布[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> U-101958 maleate 相关抗体: |
| CAS | 224170-09-6 |
| Formula | C25H33N3O5 |
| Molar Mass | 455.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gazi L, et al. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. Br J Pharmacol. 1998 Jul;124(5):889-96. [2]. De La Garza R 2nd, et al. [(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse. 2000 Sep 1;37(3):232-44. |
U-101958 maleate
CAS: 224170-09-6 F: C25H33N3O5 W: 455.55
U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC50 of 2.7
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