| Bioactivity | Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2)[1]. | ||||||||||||
| Target | 46.25 μM (BRD4-1), 62.55 μM (BRD4-2) | ||||||||||||
| Name | Tz-Thalidomide | ||||||||||||
| CAS | 2087490-42-2 | ||||||||||||
| Formula | C29H29N7O6 | ||||||||||||
| Molar Mass | 571.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934. |
Tz-Thalidomide
CAS: 2087490-42-2 F: C29H29N7O6 W: 571.58
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity
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