| Bioactivity | Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC50=2.4 μM) and topoisomerase II (IC100=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells[1][2][3]. |
| Invitro | Tyrphostin AG213 (25 μM, 50 μM, 和 75 μM; 24 h, 48 h, 和 96 h) 增加人脐静脉内皮细胞 (HUVEC) 单层的伤口闭合时间[1]。Tyrphostin AG213 (100 μM; 1 h) 干扰 HUVEC 焦点粘附和应力纤维形成[1]。Tyrphostin AG213 (100 μM; 24 h) 抑制 HUVEC 中 pp125FAK 的粘附相关酪氨酸磷酸化[1]。Tyrphostin AG213 (10 μM; 24 h) 抑制酪氨酸激酶活性，并且呈剂量和时间依赖关系地抑制 HT-29 细胞活力[2]。 |
| Name | Tyrphostin AG213 |
| CAS | 122520-86-9 |
| Formula | C10H8N2O2S |
| Molar Mass | 220.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Romer LH, et al. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol Biol Cell. 1994 Mar;5(3):349-61. |
Tyrphostin AG213
CAS: 122520-86-9 F: C10H8N2O2S W: 220.25
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC50=0.85
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